The following are the mean percentage changes (and SD) in BMD over 12 months: at L2-L4, 0.83☓.88 in the Caltrate D group and 2.84±4.04 in the Rocaltrol+Caltrate D group ( P=0.003, by ANCOVA) at the femoral neck, 0.04☓.94 in the Caltrate D group and 2.01±5.45 in the Rocaltrol+Caltrate D group ( P=0.085, by ANCOVA) and in the trochanter, 1.59±4.57 in the Caltrate D group and 3.76☖.25 in the Rocaltrol+Caltrate D group ( P=0.053, by ANCOVA). Height changes, the presence of new vertebral fractures, muscle strength and balance were evaluated. The changes in bone mineral density (BMD) served as primary end-points. Seventy-six participants received Caltrate D as one pill daily the other 74 participants received 0.25 μg Caltrate D plus Rocaltrol daily. One hundred fifty Chinese women aged over 65 years with osteopenia or osteoporosis from three centers were randomly divided into two groups. To observe the efficacy and safety of Rocaltrol (calcitriol) and/or Caltrate D (calicum carbonate plus vitamin D) in elderly Chinese women with osteopenia or osteoporosis.
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